کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3261665 | 1207704 | 2015 | 6 صفحه PDF | دانلود رایگان |
BackgroundTarget Controlled Infusion is a sophisticated tool for providing optimal sedation regimen avoiding under or oversedation in gastrointestinal endoscopy.AimsTo compare standard moderate sedation vs. non-anaesthesiologist-administered propofol sedation during gastrointestinal endoscopy.MethodsRandomized controlled trial of 70 consecutive colonoscopies and 70 consecutive esophagogastroduodenoscopies (EGD). Standard group (n = 70), received fentanyl (1 μg/kg) + midazolam (0.03–0.04 mg/kg) or midazolam only; propofol group (n = 70), received fentanyl (1 μg/kg) + propofol Target Controlled Infusion (1.2–1.6 μg/ml) or propofol Target Controlled Infusion only. Discharge time, endoscopist satisfaction and patient satisfaction were recorded in all endoscopies.ResultsColonoscopy: discharge time was significantly shorter in the propofol than the standard group (1.1 ± 0.3 vs. 5 ± 10.2 min, respectively; P = 0.03). Endoscopist satisfaction was significantly higher (98.3 ± 11.4/100 vs. 87.2 ± 12/100; P = 0.001); patient satisfaction was significantly higher (95 ± 9.3/100 vs. 85.5 ± 14.4/100; P = 0.002) in the propofol compared to the standard group.EGD: discharge time was not significantly different in the propofol and standard groups (1.1 ± 0.7 vs. 3.9 ± 9.2 min, respectively; P = 0.146). Endoscopist satisfaction was significantly higher (92.7 ± 14.3/100 vs. 82.8 ± 21.2/100; P = 0.03); patient satisfaction was significantly higher (93.8 ± 18.2/100 vs. 76.5 ± 25.2/100; P = 0.003). In the propofol group 94.3% of patients vs. 71.4% of patients in standard group asked to receive the same sedation in the future (P = 0.021).ConclusionTarget Controlled Infusion is a promising method for non-anaesthesiologist-administered propofol sedation.
Journal: Digestive and Liver Disease - Volume 47, Issue 7, July 2015, Pages 566–571