کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3262460 1207733 2013 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Early prognostic markers for fatal fulminant hepatic failure cases with viral hepatitis: Proton nuclear magnetic resonance spectroscopic studies of serum
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی غدد درون ریز، دیابت و متابولیسم
پیش نمایش صفحه اول مقاله
Early prognostic markers for fatal fulminant hepatic failure cases with viral hepatitis: Proton nuclear magnetic resonance spectroscopic studies of serum
چکیده انگلیسی

BackgroundFulminant hepatic failure is associated with liver metabolic derangements which could have fatal consequences. The aim of the present study is to identify serum markers for early prediction of the outcome.MethodsProton nuclear magnetic resonance spectroscopic studies of serum of fulminant hepatic failure patients due to viral hepatitis with grade II/III of encephalopathy (twenty-four: ten prospective and fourteen retrospective) and twenty-five controls were undertaken. Of the twenty-four patients, fifteen survived with medical management alone while nine had fatal outcome.ResultsThe results demonstrated significantly elevated indices of amino acids (alanine, lysine, glutamine, histidine, tyrosine, phenylalanine and 1,2-propanediol) in fatal cases compared to survivors and controls. Principal component analysis showed clear separation of fatal and surviving cases. Liver function parameters were significantly deranged in patients but they failed to provide early significant differences between surviving and fatal cases. Compared to Model for End-stage Liver Disease scores, Principal Component Analysis appear to be better as an early prognostic indicator. Biochemical mapping of pathways suggested interruptions in amino acid metabolism and urea cycle.ConclusionsProton nuclear magnetic resonance studies of serum have the potential of rapidly identifying patients with irreversible fulminant hepatic failure requiring liver transplantation as life saving option.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Digestive and Liver Disease - Volume 45, Issue 2, February 2013, Pages 155–163
نویسندگان
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