کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3263018 | 1207750 | 2011 | 5 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Immune-mediated diseases in primary sclerosing cholangitis Immune-mediated diseases in primary sclerosing cholangitis](/preview/png/3263018.png)
BackgroundPrimary sclerosing cholangitis is a chronic cholestatic liver disease. An immune aetiology is suggested by associations between PSC and inflammatory bowel disease. Data on concomitant prevalence of other immune-mediated diseases is limited.AimTo assess the prevalence of concomitant immune-mediated diseases and the impact on disease outcome in PSC.MethodsWe included 241 patients and retrospectively reviewed medical charts.ResultsAltogether 172 (71.4%) patients had concomitant immune-mediated disease, including IBD (149, 61.8%), autoimmune hepatitis (15, 6.2%) and other immune-mediated diseases (47, 19.5%). Thirty nine patients (22.7%) had more than one immune-mediated disease other than PSC. Most frequent extrahepatic non-IBD immune-mediated diseases were sarcoidosis, thyroid disease, and type I diabetes mellitus.Age at PSC diagnosis was lower in patients with IBD. In patients with other immune-mediated diseases than autoimmune hepatitis or IBD, age at PSC diagnosis was higher. Younger age at diagnosis and concomitant IBD related to longer survival till death or liver transplantation.ConclusionsIn a large PSC population, a high prevalence of concomitant immune-mediated diseases was found. IBD occurred more often in early-acquired PSC, and the other immune-mediated diseases more often in later-acquired PSC. No effect on outcome was found for non-IBD immune mediated disease.
Journal: Digestive and Liver Disease - Volume 43, Issue 10, October 2011, Pages 802–806