کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3263538 1207762 2010 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
13C-octanoic acid breath test (OBT) with a new test meal (EXPIROGer®): Toward standardization for testing gastric emptying of solids
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی غدد درون ریز، دیابت و متابولیسم
پیش نمایش صفحه اول مقاله
13C-octanoic acid breath test (OBT) with a new test meal (EXPIROGer®): Toward standardization for testing gastric emptying of solids
چکیده انگلیسی

BackgroundStandardization of the 13C-octanoic acid breath test is still lacking.AimTo evaluate the accuracy of the 13C-octanoic acid breath test using a new standardized ready-to-eat, gluten-, glucose-, and lactose-free muffin.MethodsHealthy subjects were recruited and sorted by sex and age. Patients with diabetic gastroparesis and untreated celiac disease with known gastric motility disorders were also tested with the new labelled muffin. Expired breath 13CO2 was analysed and t1/2 was calculated.ResultsOverall, 131 healthy subjects were enrolled. The reference range of t1/2 was 88 ± 29 min with the value of 146 min as the upper limit of normal range. No significant difference in t1/2 was found among subjects sorted by sex or age. The within-subject variability of t1/2 was 17%. Mean (±standard deviation) t1/2 values were 179 ± 50 min in patients with diabetic gastroparesis (n = 8) and 151 ± 20 min in those with untreated celiac disease (n = 11) (p ≤ 0.001 vs controls).ConclusionsA new standardized test meal simplifies the execution of the 13C-octanoic acid breath test, is not influenced by sex or age, has low intra-individual variability, is palatable, does not cause side effects, and is able to evaluate gastric emptying in both patients and healthy controls. Moreover, it can be used in subjects with lactose intolerance, diabetes, and celiac disease.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Digestive and Liver Disease - Volume 42, Issue 8, August 2010, Pages 549–553
نویسندگان
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