کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3263909 | 1207772 | 2010 | 6 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Positron emission tomography for the detection of colorectal adenomas Positron emission tomography for the detection of colorectal adenomas](/preview/png/3263909.png)
Background18F-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET) has been reported to detect colorectal adenomas.AimsThis study aimed at evaluating the sensitivity of 18F-FDG PET with computed tomography image fusion (PET/CT) for detecting colorectal adenomas.MethodsWe retrospectively compared the results of 92 18F-FDG PET/CT studies followed by colonoscopy. Colonoscopy and histology were considered as the gold standard.ResultsOne hundred fifty-seven lesions were observed. All the 12 malignancies were identified by 18F-FDG PET/CT but only 27 out of 119 resected adenomas (sensitivity 22.7%) and none of the hyperplastic polyps were detected. At the univariate and multivariate analyses there was a significant statistical association between adenomas sized more than 10 mm, presence of villous component and high-grade dysplasia and the ability of 18F-FDG PET/CT to detect adenomas. 18F-FDG PET/CT showed an overall sensitivity of 29.8%, a specificity of 81.1%, a positive predictive value (PPV) of 84.8% and a negative predictive value (NPV) of 24.6% for the neoplastic colorectal lesions globally considered.Conclusion18F-FDG PET/CT has a low sensitivity for detecting adenomas. However, because of the specificity and PPV of the technique for neoplastic colorectal lesions, the presence of a focal colorectal FDG uptake justifies the patient undergoing colonoscopy.
Journal: Digestive and Liver Disease - Volume 42, Issue 3, March 2010, Pages 185–190