کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3263962 1207774 2010 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
New-onset autoimmune hepatitis in young patients with preexisting liver disease
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی غدد درون ریز، دیابت و متابولیسم
پیش نمایش صفحه اول مقاله
New-onset autoimmune hepatitis in young patients with preexisting liver disease
چکیده انگلیسی
Autoimmune hepatitis (AIH) is thought to be a primary liver disease, occurring in the absence of any known etiology. We present three unusual cases of new-onset AIH in young female patients with longstanding preexisting liver disease (Alagille's syndrome, cystic fibrosis liver disease and sickle cell hepatopathy). All patients developed an insidious onset of abdominal pain, fatigue, jaundice and hepatitis after many years of their primary diagnosis and had negative serology for hepatitis A, B, C, cytomegalovirus and Epstein-Barr virus. The occurrence of AIH in these patients may be due to a complex interaction between the underlying liver disease, chronic medication use and genetic predisposition resulting in altered immunoregulatory mechanisms.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Digestive and Liver Disease - Volume 42, Issue 9, September 2010, Pages 657-660
نویسندگان
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