کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3264369 | 1207785 | 2011 | 6 صفحه PDF | دانلود رایگان |
BackgroundMicroscopic colitis (MC), comprising lymphocytic and collagenous colitis (LC, CC), causes chronic diarrhoea. Lansoprazole can cause MC. Likelihood criteria defining the causative relationship between drugs and MC have not been applied to lansoprazole, nor has lansoprazole-related-MC been characterized.AimTo analyse a series of lansoprazole-related MC cases, and characterize lansoprazole-related CC and LC.MethodsCases were diagnosed over 23 months and causal relationship evaluated by established likelihood criteria. A systematic Medline search was conducted and publications analysed.ResultsEight patients had lansoprazole-related MC. In all cases chronological and causality likelihood scores supported lansoprazole causative role. Discontinuation determined resolution without further treatment. Twenty-five cases of lansoprazole-related MC from 10 publications were grouped with the present series, and differences between CC and LC analysed. CC cases had more macroscopic alterations at colonoscopy (72.2 vs. 6.6%; p = 0.0002). Time between lansoprazole start and symptoms onset was longer for CC (median 60 vs. 28 days; p = 0.03).ConclusionsPeculiar features of lansoprazole-related CC were described through the analysis of a newly diagnosed lansoprazole-related MC series in which the causative role of lansoprazole was for the first time defined by established likelihood criteria, and by pooled evaluation with other cases retrieved by a systematic literature review.
Journal: Digestive and Liver Disease - Volume 43, Issue 5, May 2011, Pages 380–385