کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3264603 1207793 2009 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Acrylate glue injection for acutely bleeding oesophageal varices: A prospective cohort study
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی غدد درون ریز، دیابت و متابولیسم
پیش نمایش صفحه اول مقاله
Acrylate glue injection for acutely bleeding oesophageal varices: A prospective cohort study
چکیده انگلیسی

BackgroundAcrylate glue injection is seldom performed in patients with bleeding oesophageal varices.AimTo assess efficacy and safety of acrylate glue injection in patients with bleeding oesophageal varices, as well as the impact of this technique on subsequent variceal ligation.MethodsProspective study on 133 consecutive cirrhotic patients treated by intravariceal injection of undiluted N-butyl-2-cyanoacrylate into the bleeding varix. Outcome measures were initial haemostasis, recurrent bleeding, complications and mortality at 6 weeks.Results52 patients were actively bleeding at endoscopy and 81 showed stigmata of recent haemorrhage. Initial haemostasis was achieved in 49/52 active bleeders (94.2% [95% CI 85.1–98.5]). Overall, early recurrent bleeding occurred in 7 patients (5.2% [95% CI 2.3–10.1]). No major procedure-related complication was recorded. At 6 weeks, death occurred in 11 patients, with an overall bleeding-related mortality of 8.2% [95% CI 5.8–15.3]. Mortality was higher in active (15.4% [95% CI 6.9–28.1]) than non-active bleeders (3.7% [95% CI 0.8–10.4], OR 4.7 [95% CI 1.05–28.7], p = 0.02). Of those surviving the first bleeding episode, 112 patients subsequently underwent ligation. No technical difficulties were encountered in performing the banding procedure which was successfully completed in all cases.ConclusionsEmergency injection of acrylate glue is safe and effective for the treatment of acute bleeding oesophageal varices and does not hamper subsequent variceal ligation.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Digestive and Liver Disease - Volume 41, Issue 10, October 2009, Pages 729–734
نویسندگان
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