کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3264721 1207795 2011 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Prolonged thioguanine therapy is well tolerated and safe in the treatment of ulcerative colitis
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی غدد درون ریز، دیابت و متابولیسم
پیش نمایش صفحه اول مقاله
Prolonged thioguanine therapy is well tolerated and safe in the treatment of ulcerative colitis
چکیده انگلیسی

BackgroundThioguanine has been used for the treatment of inflammatory bowel disease, in particular for patients who failed conventional thiopurine therapy. To date, thioguanine has been infrequently studied in ulcerative colitis.AimTo evaluate the tolerability, safety and efficacy of thioguanine in the treatment of ulcerative colitis.MethodsA database analysis was performed on inflammatory bowel disease patients who had failed conventional thiopurine therapy and were treated with thioguanine. Rates and reasons for treatment failure were assessed. Laboratory values, abdominal ultrasonography, liver biopsy and endoscopic remission rates were evaluated.ResultsForty-six patients were included and median treatment duration was 22 months (range 0.3–72.0). Nine patients failed thioguanine therapy: six due to adverse events, three due to therapy resistance. Concomitant treatment with aminosalicylates protected against thioguanine failure (hazard ratio (HR) 0.11, 95% CI 0.03–0.48). When performed, ultrasonography (n = 21) revealed no suspected therapy-related pathology in all but one patient, in whom hepatomegaly was observed. Liver histology (n = 12) predominantly revealed no abnormalities (n = 4) or non-specific regeneration (n = 4); none showed nodular regenerative hyperplasia. At follow-up, 40% of colonoscopies revealed endoscopic remission as compared with 10% at baseline (P = 0.180).ConclusionsLong-term use of thioguanine appears to be well tolerated and relatively safe in ulcerative colitis patients who failed conventional thiopurine therapy.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Digestive and Liver Disease - Volume 43, Issue 2, February 2011, Pages 110–115
نویسندگان
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