کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3265498 1207816 2008 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Epidemiology, genes and inflammatory bowel diseases in childhood
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی غدد درون ریز، دیابت و متابولیسم
پیش نمایش صفحه اول مقاله
Epidemiology, genes and inflammatory bowel diseases in childhood
چکیده انگلیسی

There is evidence that inflammatory bowel disease is immunologically mediated and that genetic factors play an important aetiological role. The identification of disease susceptibility genes has led to significant progress in our understanding of the pathogenesis of Crohn's disease. Genes linked to Crohn's disease play critical roles in the normal function of the innate immune system, and genes linked to epithelial integrity may play a role in the pathogenesis of inflammatory bowel disease as well.However, the dynamic epidemiology of both Crohn's disease and ulcerative colitis suggests that extrinsic environmental factors acting at the population level may be involved in their pathogenesis. These environmental factors may be responsible for the rising incidence of inflammatory bowel disease.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Digestive and Liver Disease - Volume 40, Issue 1, January 2008, Pages 3–11
نویسندگان
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