کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3265833 1207824 2008 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
High-d-dimer plasma levels predict poor outcome in esophageal variceal bleeding
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی غدد درون ریز، دیابت و متابولیسم
پیش نمایش صفحه اول مقاله
High-d-dimer plasma levels predict poor outcome in esophageal variceal bleeding
چکیده انگلیسی

Background and AimVariceal bleeding carries a high-mortality rate in patients with liver cirrhosis. Since coagulation and fibrinolysis are abnormal in these patients we evaluated whether or not abnormalities of these haemostasis systems were independently related to mortality.MethodsGlobal coagulation, coagulation activation and fibrinolysis measurements were performed in 43 cirrhotics bleeding from esophageal varices at baseline and during follow-up and in 43 non-bleeding cirrhotic patients at baseline only.ResultsBaseline measurements of coagulation activation and fibrinolysis were more impaired in bleeders. In bleeders, prothrombin time, tissue type plasminogen activator antigen and d-dimer plasma levels were persistently more abnormal in patients who died. High-d-dimer, infection, Child-Pugh C class and MELD score ≥17 were the significant predictors of death at univariate analysis. Two different multivariate analyses to assess the independent prognostic value of these variables, one including the Child-Pugh class, the other including MELD, were performed. Independent predictors of death were high-d-dimer and infection, but not Child-Pugh class, in the former; MELD and infection, but not d-dimer, in the latter.ConclusionsBeside infection, high-d-dimer is a stronger predictor of death as compared to Child-Pugh C class, but not to a MELD score ≥17.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Digestive and Liver Disease - Volume 40, Issue 11, November 2008, Pages 874–881
نویسندگان
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