کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3265849 | 1207825 | 2007 | 6 صفحه PDF | دانلود رایگان |

Background and objectivesThe aim of this prospective, randomized study was to compare the standard regimen of midazolam and pethidine administered by the gastroenterologist versus patient controlled sedation with a propofol–fentanyl mixture during upper gastrointestinal tract endoscopic ultrasonography. Our primary end-points were patient satisfaction and patient cooperation assessed by endoscopist.MethodsFifty-four consecutive patients, undergoing endoscopic ultrasonography, received sedation with midazolam and pethidine (Group M: n = 27) or propofol and fentanyl (Group P: n = 27). Group M: pethidine 0.7 mg/kg midazolam 0.04 mg/kg before examination; boluses of same drugs if the sedation was insufficient plus a sham patient controlled sedation analgesia; Group P: propofol 17 mg plus fentanyl 15 μg before examination and a patient controlled sedation analgesia pump containing 170 mg propofol plus 150 μg fentanyl injecting 0.5 ml every time the patient pressed the button (no “lock out”). Boluses of 1 ml of the same mixture if the sedation was insufficient.ResultsGroup M: mean dosage of pethidine and midazolam 88.6 and 5 mg, respectively. Group P: mean dosage of propofol and fentanyl 119.7 mg and 106 μg, respectively. Both groups were similar for duration and difficulty of the procedure, the grade of sedation (Observer's Assessment of Alertness/Sedation Score) and judgement by endoscopist and patient about cooperation and satisfaction. The only difference between groups was about the extra boluses administered during the procedure.ConclusionThis study demonstrated that a patient controlled sedation analgesia with propofol and fentanyl is an effective and safe technique for upper gastrointestinal tract endoscopic ultrasonography procedures and results in a high level of satisfaction both for patients and operator.
Journal: Digestive and Liver Disease - Volume 39, Issue 11, November 2007, Pages 1024–1029