کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
326725 542528 2008 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Increased frequency of depressive episodes during the menopausal transition in women with bipolar disorder: Preliminary report
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
Increased frequency of depressive episodes during the menopausal transition in women with bipolar disorder: Preliminary report
چکیده انگلیسی

ObjectiveData are emerging in bipolar disorder regarding mood across phases of the female reproductive life, yet information about mood during the menopausal transition remains limited. The menopausal transition in women without mood disorders is associated with an increase in depression. This study assesses mood course during the menopausal transition in women with bipolar disorder.MethodsWe monitored mood episodes in 47 women with bipolar disorder ages 45–55 for 17.0 ± 14.0 months with systematic treatment enhancement program for bipolar disorder (STEP-BD) standardized evaluations. Charts were additionally reviewed for menstrual status and menstrual history, as well as mood episode type, duration, frequency and history.ResultsDuring the menopausal transition 68% of women with bipolar disorder experienced at least one depressive episode. Depression (but not mood elevation) episode frequency significantly increased during the menopausal transition compared to reported frequency during patients’ reproductive years. History of pre-menstrual and or post-partum mood instability did not predict perimenopausal mood episodes.ConclusionsWomen with bipolar disorder experience a high frequency of depressive episodes during perimenopausal years and this frequency appears greater than during prior reproductive years. Prospective controlled studies are needed to better understand the course of mood episodes and to enhance the effectiveness of managing bipolar disorder during the menopausal transition.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Psychiatric Research - Volume 42, Issue 3, February 2008, Pages 247–251
نویسندگان
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