کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3268711 1208096 2015 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Does inchinkoto, a herbal medicine, have hepatoprotective effects in major hepatectomy? A prospective randomized study
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی غدد درون ریز، دیابت و متابولیسم
پیش نمایش صفحه اول مقاله
Does inchinkoto, a herbal medicine, have hepatoprotective effects in major hepatectomy? A prospective randomized study
چکیده انگلیسی

ObjectivesThis randomized clinical trial was designed to investigate whether inchinkoto has a hepatoprotective effect on postoperative outcome after major hepatectomy.MethodsSixty-one patients scheduled for major hepatectomy were randomly assigned to one of two groups in which preoperative inchinkoto was (inchinkoto group, n = 30) or was not (non-inchinkoto group, n = 31) administered. Inchinkoto was administered for at least 7 days before surgery. The primary endpoint was the incidence of post-hepatectomy liver damage. The expression of nuclear factor E2-related factor 2 (Nrf2) and other oxygen stress-related markers in the liver were also determined.ResultsThere was no significant difference in clinical characteristics between the inchinkoto and non-inchinkoto groups. Serum levels in liver function tests and incidences of post-hepatectomy liver failure did not differ significantly between the two groups. However, there was a significantly higher induction of antioxidant factors in the liver, such as Nrf2 protein and heme oxygenase-1 mRNA, after hepatectomy in the inchinkoto group than in the non-inchinkoto group.ConclusionsThe preoperative administration of inchinkoto did not have a significant impact on the overall outcome of major hepatectomy. However, inchinkoto induced the expression of Nrf2 during hepatectomy and may have exerted an antioxidative effect on the liver.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: HPB - Volume 17, Issue 5, May 2015, Pages 461–469
نویسندگان
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