Subtotal hepatectomy in swine for studying small-for-size syndrome and portal inflow modulation: is it reliable?

Subtotal hepatectomy of 90% in swine is a reliable model for SFSS inducing a significant increase in HVPG. However, in view of the relevant differences between swine and human splanchnic anatomy, this model is inadequate for studying the effects of PIM by SAL and splenectomy.