کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3270018 | 1208183 | 2006 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Outcome following hepatic resection of metastatic renal tumors: the Paul Brousse Hospital experience
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
غدد درون ریز، دیابت و متابولیسم
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چکیده انگلیسی
Background: As many as 50% of patients with renal cell carcinoma (RCC) will develop systemic metastases. When hepatic metastases from RCC present in a resectable distribution, our group and other groups have previously shown that some patients benefit from curative hepatic resection. In this report we update our own experience and summarize the literature published to date on this topic. Patients and methods: From 1982 to 2005, 19 patients (9 men, 10 women, median age 50 years) with hepatic metastases from RCC were treated with hepatic resection at our institution. In 14 (74%) of the 19 patients the presentation of hepatic metastases was metachronous. Seven (37%) patients had been or were simultaneously treated for extrahepatic metastases. The mean tumor number was 2 and the mean diameter of the largest metastasis was 73 mm. Results: Marginânegative resection was achieved in 17 (89%) of 19 cases. Postoperative morbidity and mortality rates were 32% and 5%, respectively. At a median followâup interval of 26 months, 15 patients recurred with a mean time to recurrence of 12 months. The 3âyear and 5âyear diseaseâfree survival rates were 25% and 25%, respectively; 3âyear and 5âyear overall survival rates were 52% and 26%, respectively, with one patient alive 5 years following first hepatectomy. Study factors which predicted prolonged survivals included male sex and maximum tumor diameter â¤5 cm. Discussion: The overall survival rates in our series (3âyear, 52%; 5âyear, 26%) and in a complete review of the literature (3âyear, 24%; 5âyear, 18%) indicate that selected patients with hepatic metastases from RCC benefit from hepatic resection.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: HPB - Volume 8, Issue 2, April 2006, Pages 100-105
Journal: HPB - Volume 8, Issue 2, April 2006, Pages 100-105
نویسندگان
Thomas A. Aloia, René PhD, MD, Daniel Azoulay, Henri Bismuth, Denis Castaing,