کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
327087 542740 2012 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Oral treatment with amitriptyline induces coenzyme Q deficiency and oxidative stress in psychiatric patients
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
Oral treatment with amitriptyline induces coenzyme Q deficiency and oxidative stress in psychiatric patients
چکیده انگلیسی

Amitriptyline is a commonly prescribed tricyclic antidepressant, which has been shown to impair mitochondrial function and increase oxidative stress in a variety of in vitro assays. Coenzyme Q10 (CoQ10), an essential component of the mitochondrial respiratory chain and a potent antioxidant, has been proposed as a mitochondrial dysfunction marker.In order to evaluate the putative mitochondrial toxicity of amitriptyline, we have analyzed CoQ10 and ATP levels, oxidative damage and mitochondrial mass in peripheral blood cells from control healthy volunteers and psychiatric patients with depressive episodes treated or non-treated with amitriptyline. In patients not following amitriptyline treatment, CoQ10 and ATP levels and mitochondrial mass were reduced when compared to normal individuals while lipid peroxidation was clearly increased. All these alterations were aggravated in patients following oral amitriptyline therapy. These results suggest that mitochondrial dysfunction could be involved in the pathophysiology of depression and may be worsened by amitriptyline treatment. CoQ10 supplementation is postulated to counteract the adverse effects of amitriptyline treatment in psychiatric patients.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Psychiatric Research - Volume 46, Issue 3, March 2012, Pages 341–345
نویسندگان
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