Vildagliptine versus sitagliptine en addition à la metformine : sont-elles équivalentes ? Résultats de l'étude OPTIMA

The addition of each DPP-4 inhibitor significantly reduced glycemic variability with no difference between the two drugs. However, vildagliptin was associated with better circadian glycemic control than sitagliptin and with a significant decrease in overall hyperglycemia, mainly driven by a reduction in basal hyperglycemia.