کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
327505 542912 2010 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Rapid antipsychotic response with ziprasidone predicts subsequent acute manic/mixed episode remission
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
Rapid antipsychotic response with ziprasidone predicts subsequent acute manic/mixed episode remission
چکیده انگلیسی

ObjectiveTo assess rapid antipsychotic efficacy with oral ziprasidone monotherapy in bipolar acute manic/mixed episodes with psychotic features, and predictive value of rapid antipsychotic response for subsequent acute manic/mixed episode remission.MethodsPooled analysis of two 3-week, randomized, double-blind, placebo-controlled trials of ziprasidone (40–160 mg/d) in inpatients with bipolar I disorder, and a current manic or mixed episode, with (n = 152) or without (n = 246) psychotic features. Psychosis improvement was evaluated by change in SADS-C psychosis score (sum of delusions, hallucinations, and suspiciousness items). Rapid antipsychotic response (⩾50% decrease in SADS-C psychosis score by Day 4) and acute manic episode response and remission (endpoint ⩾50% MRS decrease, and a MRS score ⩽ 12, respectively) were analyzed.ResultsSignificantly greater antipsychotic effects were observed by Day 4 with ziprasidone treatment (vs. placebo) and the magnitude of improvement increased significantly with time, in all subjects, in the subgroup of all psychotic subjects, and psychotic subjects with low baseline agitation (p < 0.05). Rapid antipsychotic response predicted subsequent acute manic episode remission independent of ziprasidone or placebo treatment received (p < 0.001, ROC AUC = 0.71) with significant improvement in accuracy of MRS remission prediction when compared to models using early changes in MRS score alone (p = 0.01).LimitationsPost hoc analysis, use of 3 SADS-C psychosis items to assess psychosis.ConclusionsThe predictive value of rapid (Day 4) improvement in psychotic symptoms for subsequent (Day 21) remission of acute manic/mixed symptoms may facilitate enhanced therapeutics, in view of the current practice of brief hospitalization for patients with acute manic/mixed episodes with psychotic features.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Psychiatric Research - Volume 44, Issue 1, January 2010, Pages 8–14
نویسندگان
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