Inhibiteurs du cotransporteur sodium-glucose de type 2 (SGLT2) : une nouvelle approche thérapeutique pour le diabète de type 2 ?

The kidney has an important role in glucose metabolism and regulation. The renal sodium glucose co-transporter 2 (SGLT2) has a key role in the active transport of glucose by determining renal glucose reabsorption, thus representing a potential target for pharmacological diabetes treatment. Effects of SGLT2 inhibitors in various animal models, as well as currently available phase 2 clinical results with oral selective SGLT2 inhibitors in type 2 diabetic patients are presented and discussed.