کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
328023 543050 2008 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The cerebellum in mild cognitive impairment and Alzheimer’s disease – A structural MRI study
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
The cerebellum in mild cognitive impairment and Alzheimer’s disease – A structural MRI study
چکیده انگلیسی

Neuropathological research consistently revealed the cerebellum to undergo degenerative changes in Alzheimer’s disease (AD). Whether these alterations affect cerebellar morphology in vivo has not yet been investigated in a comprehensive way. Magnetic resonance imaging was performed in 20 patients with AD, 20 with mild cognitive impairment (MCI), and 20 healthy controls. By manual tracing the cerebellum was divided in four substructures (anterior lobe, superior posterior lobe, inferior posterior lobe and corpus medullare, respectively) on each hemisphere. Posterior cerebellar lobes were significantly smaller in AD patients when compared to healthy controls. In the AD group, atrophy of the posterior cerebellar regions was associated with poorer cognitive performance. Our findings lend further support for cerebellar involvement in AD.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Psychiatric Research - Volume 42, Issue 14, October 2008, Pages 1198–1202
نویسندگان
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