کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3282601 | 1209151 | 2014 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Liver Injury Is Common Among Chronic Abusers of Ketamine
ترجمه فارسی عنوان
آسیب کبدی در میان عفونتهای مزمن کتامین است
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
بیماریهای گوارشی
چکیده انگلیسی
Abuse of ketamine leads to liver injury. We investigated the histopathologic and radiologic features of ketamine abusers with significant liver injury in a cross-sectional survey of 297 consecutive chronic abusers of ketamine with urinary tract dysfunction. Liver biopsy and magnetic resonance cholangiopancreatography were performed in patients with liver injury (concentrations of bilirubin, alkaline phosphatase, and/or alanine aminotransferase >2-fold the upper limit of normal). The prevalence of liver injury was 9.8% (all cases cholestatic). Bile duct injury was observed in all 7 patients assessed by liver biopsy. Two patients had bridging fibrosis despite their young age. Three of 6 patients who underwent magnetic resonance cholangiopancreatography examination were found to have prominent or dilated common bile ducts without obstructions or extrinsic compressions. Ketamine abuse therefore appears to lead to common bile duct dilatation, microscopic bile duct injury, and even significant liver fibrosis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Gastroenterology and Hepatology - Volume 12, Issue 10, October 2014, Pages 1759-1762.e1
Journal: Clinical Gastroenterology and Hepatology - Volume 12, Issue 10, October 2014, Pages 1759-1762.e1
نویسندگان
Grace Lai-Hung Wong, Yuk-Him Tam, Chi-Fai Ng, Anthony Wing-Hung Chan, Paul Cheung-Lung Choi, Winnie Chiu-Wing Chu, Paul Bo-San Lai, Henry Lik-Yuen Chan, Vincent Wai-Sun Wong,