کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3284779 1209212 2007 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A Familial Component to Human Rectal Cancer, Independent of Colon Cancer Risk
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی بیماری‌های گوارشی
پیش نمایش صفحه اول مقاله
A Familial Component to Human Rectal Cancer, Independent of Colon Cancer Risk
چکیده انگلیسی

Background & Aims: The Utah Population Database (UPDB) is unique; it links genealogy for over 2 million Utah individuals to a statewide Cancer Registry. We have investigated the familial nature of rectal cancer, considered independently from colon cancer. Methods: We estimated relative risks in relatives, and average relatedness among rectal cancer patients using matched controls from the UPDB. Results: There is a significant increased risk for rectal cancer in first-degree relatives of rectal cancer patients (relative risk [RR], 1.97), equivalent to the risk for colon cancer (RR, 2.11). The significant increased risk for rectal cancer extends to second- and third-degree relatives. The RR for rectal cancer among first-degree relatives of young-onset rectal cancer patients (<55 y), is equivalent (RR, 3.34) to their risk of colon cancer (RR, 3.35). Conclusions: The UPDB provides strong evidence for a familial component to rectal cancer that may include a genetic component in addition to shared environment. There is a significant increased risk of rectal cancer in the close and distant relatives of rectal cancer patients, which is even higher among relatives of young-onset patients. Although it has been reported that relatives of colon cancer probands are at increased risk for colorectal cancer, the risk of large-bowel cancer among relatives of rectal cancer patients has been less clear. Relatives of rectal cancer probands experience a risk of cancer of the large bowel that is at least as high as the risk previously reported for relatives of individuals with colon cancer.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Gastroenterology and Hepatology - Volume 5, Issue 9, September 2007, Pages 1080–1084
نویسندگان
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