کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3285514 | 1209231 | 2006 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Natural History of Intraductal Papillary Mucinous Tumors of the Pancreas: Actuarial Risk of Malignancy
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
mPDMRCPHGDLGDEUS-FNAIPMTEndoscopic retrograde cholangiopancreatography - cholangiopancreatography رتروگراد endoscopicmagnetic resonance cholangiopancreatography - تشدید مغناطیسی cholangiopancreatographycomputed tomography - توموگرافی کامپیوتری یا سی تی اسکن یا مقطعنگاری رایانهایhigh-grade dysplasia - دیسپلازی درجه بالاlow-grade dysplasia - دیسپلازی کم درجهInvasive carcinoma - کارسینوم invasiivebranch duct - کانال شاخهmain pancreatic duct - کانال پانکراس اصلیERCP یا endoscopic retrograde cholangiopancreatography - کلانژیوگرافی آندوسکوپیک عقبگرد یا ایآرسیپی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
بیماریهای گوارشی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Natural History of Intraductal Papillary Mucinous Tumors of the Pancreas: Actuarial Risk of Malignancy Natural History of Intraductal Papillary Mucinous Tumors of the Pancreas: Actuarial Risk of Malignancy](/preview/png/3285514.png)
چکیده انگلیسی
Background & Aims: Natural history of intraductal papillary mucinous tumors of the pancreas (IPMTs) is unknown. Cross-sectional studies suggest that exclusive branch duct (BD) involvement is associated with a lower risk of carcinoma than main pancreatic duct (MPD) involvement. The aim of our study was to calculate longitudinal risk of malignant transformation of IPMT since the first sign. Methods: All the patients with a diagnosis of highly probable or histologically proven IPMT were included. Actuarial risks of occurrence of at least low-grade dysplasia (â¥LGD), high-grade dysplasia (â¥HGD), or invasive carcinoma (IC) were calculated by Kaplan-Meier method from the first sign attributable to IPMT. The risks according to sex, acute pancreatitis, tumor size, and involvement of MPD were compared by log-rank test. Results: One hundred six patients were included with a proven (n = 76) or probable (n = 30) IPMT. The tumor was confined to BD in 53 cases. Median duration since the onset of the first sign to the end of follow-up was 21 months (range, 0-241). Ten-year actuarial risk that IPMT grade was â¥LGD, â¥HGD, or IC was 67%, 49%, and 29%, respectively. The only morphologic risk factor of malignant transformation was involvement of MPD, with a 5-year actuarial risk of â¥HGD of 63% in the MPD group compared with 15% in the BD group (P < .001). Conclusions: Longitudinal risk of at least HGD or IC is time-dependent. Patients with BD IPMT present a much lower risk, justifying a nonoperative surveillance.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Gastroenterology and Hepatology - Volume 4, Issue 4, April 2006, Pages 460-468
Journal: Clinical Gastroenterology and Hepatology - Volume 4, Issue 4, April 2006, Pages 460-468
نویسندگان
Philippe Lévy, Vincent Jouannaud, Dermot O'Toole, Anne Couvelard, Marie Pierre Vullierme, Laurent Palazzo, Alain Aubert, Philippe Ponsot, Alain Sauvanet, Frédérique Maire, Olivia Hentic, Pascal Hammel, Philippe Ruszniewski,