کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3285552 | 1209232 | 2008 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Endoscopic or Percutaneous Biliary Drainage for Gallbladder Cancer: A Randomized Trial and Quality of Life Assessment
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کلمات کلیدی
GBCEuropean Organization for Research and Treatment of Cancer Quality of Life QuestionnaireCECTPTBDEndoscopic stenting - استنت گذاری آندوسکوپیcontrast-enhanced computed tomography - توموگرافی کامپیوتری با کنتراستpercutaneous transhepatic biliary drainage - زهکشی صفراوی از طریق پوستیGallbladder cancer - سرطان کیسه صفراUltrasonography - سونوگرافی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
بیماریهای گوارشی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Background & Aims: Patients with carcinoma of the gallbladder (GBC) and obstructive jaundice are usually not amenable to curative resection. Effective palliation by biliary decompression is the goal of treatment. Endoscopic stenting (ES) and percutaneous transhepatic biliary drainage (PTBD) can provide biliary decompression. We compared unilateral PTBD and ES in patients with a hilar block caused by GBC and assessed their quality of life (QOL). Methods: Consecutive patients with GBC not suitable for curative resection with Bismuth type 2 or 3 block were randomized to either PTBD or ES with a 10F plastic stent. Technical success, successful drainage, early cholangitis, complications, procedure-related mortality, 30-day mortality, survival, and QOL before and 1 and 3 months after stenting were compared between the 2 groups. All patients were followed up until death. Results: Fifty-four patients were randomized to PTBD or ES (27 each). Successful drainage was better in the PTBD group (89% vs 41%; P < .001). Early cholangitis was significantly higher in the ES group (48% vs 11%; P = .002). Procedure-related (4% vs 8%) and 30-day mortality (4% vs 8%) and median survival were similar (60 days in both; P = .71). Although the World Health Organization-Quality of Life 1- and 3-month physical and psychological scores were better after PTBD, the difference was not significant. The European Organization for Research and Treatment of Cancer (EORTC)-Quality of Life Questionnaire 30 global health status at 3 months was significantly better after PTBD (75 vs 30.5, P = .02). The EORTC symptom scores improved in both groups, but only fatigue was significantly better after PTBD. Conclusions: PTBD provides better biliary drainage and has lower complication rates in patients with GBC and hilar block.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Gastroenterology and Hepatology - Volume 6, Issue 8, August 2008, Pages 944-950.e3
Journal: Clinical Gastroenterology and Hepatology - Volume 6, Issue 8, August 2008, Pages 944-950.e3
نویسندگان
Sundeep Singh Saluja, Manpreet Gulati, Pramod Kumar Garg, Hemraj Pal, Sujoy Pal, Peush Sahni, Tushar K. Chattopadhyay,