کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3285969 | 1209254 | 2006 | 14 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Advances in Chemotherapy for Colorectal Cancer
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کلمات کلیدی
EGFRNSABPFOLFIRICALGBFolfoxMSIDFSIrOx5-FUApr - آوریلIFL - ایفلاabdominoperineal resection - برداشتن شکم شکمdisease-free survival - بقاء بدون بیماریoverall survival - بقای کلMicrosatellite instability - بی ثباتی ریزماهواره ایColorectal cancer - سرطان روده بزرگcancer and leukemia Group B - سرطان و لوسمی گروه BVascular endothelial growth factor - فاکتور رشد اندوتلیال عروقیVascular Endothelial Growth Factor (VEGF) - فاکتور رشد اندوتلیال عروقی (VEGF)5-fluorouracil - فلوروراسیل-۵، فلوئورواوراسیلLeucovorin - لوووورینNational Surgical Adjuvant Breast and Bowel Project - پروژه ملی جراحی پستان و باس جراحیCRC - کد افزونگی دورهای Epidermal growth factor receptor - گیرنده فاکتور رشد اپیدرمال
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
بیماریهای گوارشی
پیش نمایش صفحه اول مقاله
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چکیده انگلیسی
Gastroenterologists have a primary role in the management of colorectal cancer patients in that they frequently establish the diagnosis, direct or perform tumor staging evaluations, and initiate referrals for oncologic treatment. Several important advances have been made in the adjuvant treatment of colon and rectal cancers and in therapy of metastatic disease. These advances include the development of more effective combination chemotherapy regimens and molecularly targeted antibodies. These antibodies are directed against regulators of angiogenesis (vascular endothelial growth factor) and tumor cell growth (epidermal growth factor receptor) and have been shown to enhance the efficacy of cytotoxic chemotherapy. In the treatment of localized rectal cancer, the integration of chemotherapy and radiation with surgery has resulted in neoadjuvant approaches that achieve improved tumor control, sphincter preservation, and reduce treatment-related toxicities. This review presents an update of the current approach to colon and rectal cancer treatment, highlighting recent chemotherapeutic advances in the management of these highly prevalent malignancies.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Gastroenterology and Hepatology - Volume 4, Issue 7, July 2006, Pages 808-821
Journal: Clinical Gastroenterology and Hepatology - Volume 4, Issue 7, July 2006, Pages 808-821
نویسندگان
Dirk M. Bernold, Frank A. Sinicrope,