کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3286116 1209284 2016 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
MicroRNAs in cholangiopathies: Potential diagnostic and therapeutic tools
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی بیماری‌های گوارشی
پیش نمایش صفحه اول مقاله
MicroRNAs in cholangiopathies: Potential diagnostic and therapeutic tools
چکیده انگلیسی

SummaryCholangiopathies are the group of diseases targeting the bile duct epithelial cells (i.e. cholangiocytes). These disorders arise from different etiologies and represent a current diagnostic, prognostic and therapeutic challenge. Different molecular mechanisms participate in the development and progression of each type of biliary disease. However, microRNA deregulation is a common central event occurring in all of them that plays a key role in their pathogenesis. MicroRNAs are highly stable small non-coding RNAs present in cells, extracellular microvesicles and biofluids, representing valuable diagnostic tools and potential targets for therapy. In the following sections, the most novel and significant discoveries in this field are summarized and their potential clinical value is highlighted.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinics and Research in Hepatology and Gastroenterology - Volume 40, Issue 1, February 2016, Pages 15–27
نویسندگان
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