کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3286179 | 1209286 | 2015 | 6 صفحه PDF | دانلود رایگان |
SummaryHepatocellular adenomas (HCAs) are heterogeneous group of benign tumors; three pathomolecular subtypes have been identified so far: hepatocyte nuclear factor 1 α–inactivated HCA (H-HCA) (35–40%), inflammatory HCA (I-HCA) (> 50%), β-catenin activated HCA (10%). Ten percent of I-HCA are also β-catenin activated. We report a rare case of three histologically confirmed steatotic HCAs of three different phenotypes: I-HCA, β-catenin activated I-HCA, and H-HCA in a 36-year-old woman. This observation outlines that in the same patient, HCA may be of different subtypes. The predisposition to develop different HCA hypothetically caused by a “benign tumorigenic field effect” may result, even rarely, in different genotypes/phenotypes such as H-HCA and I-HCA. Moreover, we illustrate the very high specificity of MR for subtyping HCA.
Journal: Clinics and Research in Hepatology and Gastroenterology - Volume 39, Issue 2, April 2015, Pages e17–e22