کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3286526 1209301 2013 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Metal versus plastic stents for malignant biliary obstruction: An update meta-analysis
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی بیماری‌های گوارشی
پیش نمایش صفحه اول مقاله
Metal versus plastic stents for malignant biliary obstruction: An update meta-analysis
چکیده انگلیسی

SummaryBackground and objectiveThe data on comparisons of stent patency, re-intervention rate and patient survival between metal and plastic stents in palliation of malignant biliary obstruction have never been pooled. We carry out a meta-analysis to summarise current evidence for clinical efficacy of metal and plastic stents in the treatment of malignant biliary obstruction.MethodsA comprehensive search of several databases was conducted. A fixed-effects or random-effects model was used to pool data of all study endpoints. Sensitivity analysis and subgroup analysis (distal vs. hilar biliary obstruction) were also performed.ResultsTen randomized clinical trials were identified. Compared with plastic stents, metal stents were associated with a significantly longer stent patency (HR = 0.36; 95% CI: 0.28–0.47; I2 = 0%), fewer numbers of re-intervention (WMD = 0.59; 95% CI: 0.28–0.90; I2 = 76.4%) and longer patient survival (HR = 0.74; 95% CI: 0.64–0.85; I2 = 16.0%). These results were still significant by sensitivity analysis. All outcomes reached statistical significance except of the pooled WMD of number of re-intervention in the studies with hilar biliary obstruction. No publication bias was observed.ConclusionsMetal stents were associated with a significantly longer stent patency, lower re-intervention rate and longer patient survival in palliation of malignant biliary obstruction when compared to plastic stents.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinics and Research in Hepatology and Gastroenterology - Volume 37, Issue 5, November 2013, Pages 496–500
نویسندگان
, , , , ,