کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3286545 1209302 2011 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The role of the pathologist in diagnosing and grading biliary diseases
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی بیماری‌های گوارشی
پیش نمایش صفحه اول مقاله
The role of the pathologist in diagnosing and grading biliary diseases
چکیده انگلیسی

SummaryPathological features of primary biliary cirrhosis (PBC) are reviewed. Immune-mediated, non-suppurative cholangitis is the initial lesion and is followed by the gradual and extensive destruction of bile ducts and development of chronic cholestasis. Simultaneously, necro-inflammatory activities of the hepatic parenchyma and limiting plates of milder form develop not infrequently. Eventually, liver fibrosis and cirrhosis develop. A new system applicable to needle liver biopsies in which staging is evaluated using a combination of three factors (fibrosis, cholestasis, and bile duct loss) and necro-inflammatory activities of the bile duct and hepatic parenchyma are graded, is proposed. The clinical and therapeutic evaluation of PBC using this system is warranted.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinics and Research in Hepatology and Gastroenterology - Volume 35, Issue 5, May 2011, Pages 347–352
نویسندگان
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