Impact of metabolic syndrome on oncologic outcome after radical gastrectomy for gastric cancer

SummaryBackgroundFew studies have reported the relationship between MS and the prognosis of gastric cancer.MethodsData were collected from 505 patients who underwent radical gastrectomy for gastric cancer between January 2006 and December 2007. After exclusion, remaining 204 patients were divided into two groups based on the presence of MS.ResultsNo significant differences were observed in tumor stage and grade between the MS (n = 60) and non-MS (n = 144) groups. The median follow-up periods were 53.2 ± 23.5 and 54.7 ± 22.1 months in for the MS and non-MS groups, respectively (P = 0.677). Seventeen (28.3%) and 21 (14.6%) patients showed tumor recurrence in the MS and non-MS groups, respectively (P = 0.022). In addition, disease-free survival of patients in the MS group was less than in non-MS group (P = 0.036). The Cox regression hazard model demonstrated that advanced tumor stage (stage III or IV, HR = 17.8, 95% CI = 5.3 to 59.4) and presence of MS (HR = 2.8, 95% CI = 1.3 to 5.8) were independent risk factors for recurrence.ConclusionMS may be an important prognostic factor for gastric cancer. Control of MS could improve the therapeutic efficacy of gastric cancer.