کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3286618 | 1209305 | 2013 | 6 صفحه PDF | دانلود رایگان |
SummaryBackgroundNon-alcoholic fatty liver disease (NAFLD) ranges from simple steatosis to steatohepatitis, and cirrhosis in patients with alcohol intake less than 20 g/day, and is usually associated with insulin resistance (IR).AimGiven that no drugs are specifically approved for NAFLD, we tested the efficacy of a non-pharmacological multidisciplinary intervention based on a personalized diet, physical activity and behavior therapy.MethodsIn this open non-randomized study, personalized diet, physical exercise and behaviour therapy for 3 months were prescribed in 12 consecutive patients with NAFLD. Lifestyle, including total caloric intake, physical activity and resting energy expenditure was monitored by a SenseWear Armband. Insulin Resistance (IR) was measured by HOMA and oral glucose insulin sensitivity tests (OGIS); fat liver content was estimated by two different semi-quantitative scores and by the Doppler Power Index (DPI).ResultsData show that the multidisciplinary intervention produced a significant reduction of total caloric intake, a 8% reduction in body weight, a modest increase in daily physical activity, a significant (P < 0.001) reduction of aminotransferases and a decrease of total hepatic fat content.ConclusionsA 3-month multidisciplinary intervention inducing at least 8% of weight loss, improves liver tests and decreases liver fat content.
Journal: Clinics and Research in Hepatology and Gastroenterology - Volume 37, Issue 4, September 2013, Pages 353–358