کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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328694 | 1433627 | 2009 | 8 صفحه PDF | دانلود رایگان |
BackgroundThe positron emission tomography (PET) tracer [11C]-Pittsburgh Compound-B ([11C]PIB) allows the in vivo assessment of amyloid plaque burden in the brain. In a cross-sectional study we examined the association between the severity of dementia assessed using the Clinical Dementia Rating scale sum of boxes (CDR-SOB) and [11C]PIB-PET in patients with Alzheimer's disease (AD).MethodsPatients with probable AD who had an AD-typical [18F]FDG-PET scan were included. Linear regression analysis in anatomically defined regions-of-interest (ROIs) and correlation analysis using statistical parametric mapping (SPM) were used to determine the association between CDR-SOB and [11C]PIB uptake.ResultsThe linear regression analyses showed that the CDR-SOB explained approximately 11–22% of the variance of [11C]PIB uptake. The association attained statistical significance in both frontal, in both anterior cingulate cortices, and in both putamina. The SPM analysis showed a significant association in more widespread regions of the brain, with maxima located in similar areas as in the ROI-analysis.ConclusionThe CDR-SOB score is significantly associated with [11C]PIB uptake in patients with AD. Thus [11C]PIB is a potential surrogate marker of dementia severity.
Journal: Neurobiology of Aging - Volume 30, Issue 12, December 2009, Pages 1902–1909