کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
328768 1433659 2007 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Measurement of hippocampal subfields and age-related changes with high resolution MRI at 4 T
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
پیش نمایش صفحه اول مقاله
Measurement of hippocampal subfields and age-related changes with high resolution MRI at 4 T
چکیده انگلیسی

Histological studies suggest that hippocampal subfields are differently affected by aging and Alzheimer's disease (AD). The aims of this study were: (1) To test if hippocampal subfields can be identified and marked using anatomical landmarks on high resolution MR images obtained on a 4T magnet. (2) To test if age-specific volume changes of subfields can be detected. Forty-two healthy controls (21–85 years) and three AD subjects (76–86 years) were studied with a high resolution T2 weighted fast spin echo sequence. The entorhinal cortex (ERC), subiculum, CA1, CA2 and CA3/4 and dentate were marked. A significant correlation between age and CA1 (r = −0.51, p = 0.0002) which was most pronounced in the seventh decade of life was found in healthy controls. In AD subjects, CA1 and subiculum were smaller than in age-matched controls. These preliminary findings suggest that measurement of hippocampal subfields may be helpful to distinguish between normal aging and AD.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Aging - Volume 28, Issue 5, May 2007, Pages 719–726
نویسندگان
, , , , , , ,