کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3288582 | 1209520 | 2010 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Levosulpirida en el manejo de la dispepsia funcional y la gastroparesia
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
بیماریهای گوارشی
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چکیده انگلیسی
Levosulpiride is a sulpiride isomer that exerts its prokinetic action through a dual mechanism: 1) as a D2 dopamine receptor antagonist and 2) as a serotonin 5HT4 receptor agonist, conferring this drug with a cholinergic effect. At a dosage of 25Â mg three times daily, levosulpiride accelerates gastric and gallbladder emptying. Clinical trials have shown that this agent is more effective than placebo in reducing the symptoms of dyspepsia, while comparative studies have demonstrated that its effect is similar or superior to that of other dopamine antagonists. The safety profile of levosulpiride is good and the frequency of adverse events is similar to that of other D2 dopamine antagonists. Therefore, this drug is a useful therapeutic option in the management of patients with functional dyspepsia, as well as in those with delayed gastric emptying.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: GastroenterologÃa y HepatologÃa - Volume 33, Issue 8, October 2010, Pages 586-590
Journal: GastroenterologÃa y HepatologÃa - Volume 33, Issue 8, October 2010, Pages 586-590
نویسندگان
Jordi Serra,