کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
329153 | 1433601 | 2011 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Carvedilol as a potential novel agent for the treatment of Alzheimer's disease
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
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چکیده انگلیسی
Oligomeric β-amyloid (Aβ) has recently been linked to synaptic plasticity deficits, which play a major role in progressive cognitive decline in Alzheimer's disease (AD). Here we present evidence that chronic oral administration of carvedilol, a nonselective β-adrenergic receptor blocker, significantly attenuates brain oligomeric β-amyloid content and cognitive deterioration in 2 independent AD mouse models. We found that carvedilol treatment significantly improved neuronal transmission, and that this improvement was associated with the maintenance of number of the less stable “learning” thin spines in the brains of AD mice. Our novel observation that carvedilol interferes with the neuropathologic, biochemical, and electrophysiological mechanisms underlying cognitive deterioration in AD supports the potential development of carvedilol as a treatment for AD.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Aging - Volume 32, Issue 12, December 2011, Pages 2321.e1-2321.e12
Journal: Neurobiology of Aging - Volume 32, Issue 12, December 2011, Pages 2321.e1-2321.e12
نویسندگان
Jun Wang, Kenjiro Ono, Dara L. Dickstein, Isabel Arrieta-Cruz, Wei Zhao, Xianjuan Qian, Ashley Lamparello, Rakesh Subnani, Mario Ferruzzi, Constantine Pavlides, Lap Ho, Patrick R. Hof, David B. Teplow, Giulio M. Pasinetti,