کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3292300 1209783 2014 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Role of the Intestinal Microbiota in Resistance to Colonization by Clostridium difficile
ترجمه فارسی عنوان
نقش میکروبیوتایای روده در مقاومت به کلونیستیوم دیفیسیل به کلونیزاسیون
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی بیماری‌های گوارشی
چکیده انگلیسی

Antibiotic-associated infection with the bacterial pathogen Clostridium difficile is a major cause of morbidity and increased health care costs. C difficile infection follows disruption of the indigenous gut microbiota by antibiotics. Antibiotics create an environment within the intestine that promotes C difficile spore germination, vegetative growth, and toxin production, leading to epithelial damage and colitis. Studies of patients with C difficile infection and animal models have shown that the indigenous microbiota can inhibit expansion and persistence of C difficile. Although the specific mechanisms of these processes are not known, they are likely to interfere with key aspects of the pathogen’s physiology, including spore germination and competitive growth. Increasing our understanding of how the intestinal microbiota manage C difficile could lead to better means of controlling this important nosocomial pathogen.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gastroenterology - Volume 146, Issue 6, May 2014, Pages 1547–1553
نویسندگان
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