کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
329490 1433633 2009 16 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The modulation of striatal dopamine release correlates with water-maze performance in aged rats
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
پیش نمایش صفحه اول مقاله
The modulation of striatal dopamine release correlates with water-maze performance in aged rats
چکیده انگلیسی

Cluster analysis of performance during acquisition of a place-learning task in the water maze distinguished between subpopulations of aged rats (25–27 months) classified as moderately (AMI) or severely impaired (ASI) in comparison with young adults (3–5 months). Using a slice-superfusion device, electrically or nicotine-evoked release of dopamine from striatum was assessed in the presence of GR-55,562 (5-HT1B receptor antagonist), methiotepin (mixed 5-HT1/2 receptor antagonist) and/or sulpiride (D2/D3 receptor antagonist). The main neuropharmacological results demonstrated age-related alterations in the 5-HT1B- and D2/D3-mediated modulation of electrically evoked striatal dopamine release. Regression analyses indicated a possible contribution of such alterations to the age-related behavioural deficits: the larger the deficit, the weaker the electrically evoked release under 5-HT1B and D2/D3 receptor blockade. Extending our recent report on the modulation of striatal acetylcholine release in aged rats [Cassel et al., 2007. Neurobiol. Aging 28, 1270–1285], these new findings make dopaminergic and serotonergic functional alterations potential candidates to participate in age-related deficits in the water maze, most probably in interaction with formerly described cholinergic dysfunctions.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Aging - Volume 30, Issue 6, June 2009, Pages 957–972
نویسندگان
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