کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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329490 | 1433633 | 2009 | 16 صفحه PDF | دانلود رایگان |

Cluster analysis of performance during acquisition of a place-learning task in the water maze distinguished between subpopulations of aged rats (25–27 months) classified as moderately (AMI) or severely impaired (ASI) in comparison with young adults (3–5 months). Using a slice-superfusion device, electrically or nicotine-evoked release of dopamine from striatum was assessed in the presence of GR-55,562 (5-HT1B receptor antagonist), methiotepin (mixed 5-HT1/2 receptor antagonist) and/or sulpiride (D2/D3 receptor antagonist). The main neuropharmacological results demonstrated age-related alterations in the 5-HT1B- and D2/D3-mediated modulation of electrically evoked striatal dopamine release. Regression analyses indicated a possible contribution of such alterations to the age-related behavioural deficits: the larger the deficit, the weaker the electrically evoked release under 5-HT1B and D2/D3 receptor blockade. Extending our recent report on the modulation of striatal acetylcholine release in aged rats [Cassel et al., 2007. Neurobiol. Aging 28, 1270–1285], these new findings make dopaminergic and serotonergic functional alterations potential candidates to participate in age-related deficits in the water maze, most probably in interaction with formerly described cholinergic dysfunctions.
Journal: Neurobiology of Aging - Volume 30, Issue 6, June 2009, Pages 957–972