Release of Endogenous Opioids From Duodenal Enteroendocrine Cells Requires Trpm5

Solitary chemosensory cells that coexpress β-endorphin, Met-enkephalin, uroguanylin, and Trpm5 exist in mouse duodenum. These cells are likely to secrete the bioactive peptides into the intestinal lumen in response to dietary factors; release of the opioid peptides requires the Trpm5 ion channel.