کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3296379 | 1209868 | 2008 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Substance P as a Novel Anti-obesity Target
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کلمات کلیدی
NPYDEXApro-opiomelanocortinDIONK-1RPOMCTNFαGTTinsulin tolerance test - آزمون تحمل انسولینITT - اینجاglucose tolerance test - تست تحمل گلوکزtumor necrosis factor α - تومور نکروز عامل αdual energy X-ray absorptiometry - جذب سنجی اشعه ایکس انرژی دوگانهSubstance P - ماده PArbitrary Unit - واحد خودآموزdiet-induced obesity - چاقی ناشی از رژیم غذاییNeurokinin-1 receptor - گیرنده نوروکینین-1
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
بیماریهای گوارشی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Background & Aims: Substance P (SP) is an 11-amino acid peptide that belongs to the tachykinin family of peptides. SP acts in the brain and in the periphery as a neuropeptide, neurotransmitter, and hormone affecting diverse physiologic pathways, mainly via its high-affinity neurokinin-1 receptor (NK-1R). Its presence in the hypothalamus and other areas of the brain that regulate feeding as well as in the stomach and small intestine prompted us to investigate its role on appetite control and energy balance. Methods: CJ 012,255 (CJ), a SP antagonist that binds to NK-1R, was injected into lean, diet-induced obese (DIO), and genetically obese (ob/ob) mice, and its effects on body weight, adiposity, and insulin sensitivity were investigated. Results: CJ administration prevented weight gain and accumulation of fat after 2 weeks of high-fat feeding, whereas similar CJ treatment in obese mice (following 3 months of high-fat diet) resulted in weight loss, reduction in adiposity, and improvement of insulin sensitivity, in part because of inhibition of food intake. The effects of SP in the control of energy balance are, at least in part, leptin independent because CJ treatment was also effective in leptin-deficient mice. Peripheral SP administration resulted in a mild, dose-dependent increase in food intake, evident 3 hours post-SP injection. Conclusions: CJ reduces appetite and promotes weight loss in mice. We speculate that NK-1R antagonists, already tested in clinical trials for various diseases, may represent a potential target against obesity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gastroenterology - Volume 134, Issue 3, March 2008, Pages 747-755.e1
Journal: Gastroenterology - Volume 134, Issue 3, March 2008, Pages 747-755.e1
نویسندگان
Iordanes Karagiannides, Daniel Torres, Yu-Hua Tseng, Collin Bowe, Eugenia Carvalho, Daniel Espinoza, Charalabos Pothoulakis, Efi Kokkotou,