کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3297628 | 1209887 | 2006 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
CD4+ T-Cell Modulation of Visceral Nociception in Mice
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
بیماریهای گوارشی
پیش نمایش صفحه اول مقاله
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چکیده انگلیسی
Background & Aims: Although inflammatory and immune cells are present in the gut in the absence of pathology, their presence does not result in sensitization of sensory nerves, implying the existence of a local antinociceptive influence. We hypothesized that a component of the immune system exerts an antinociceptive influence, thus enabling the gut to function in the absence of undue pain or discomfort. Methods: Visceromotor responses to colorectal distention were measured in mice with severe combined immune deficiency (SCID) and their wild-type controls. Results: SCID mice exhibited significantly lower pain thresholds. Transfer of CD4+ T, but not B lymphocytes, normalized visceral pain in these mice. The restoration of normal visceral nociception following T-cell reconstitution in SCID mice was blocked by naloxone methiodide. Using an enzyme immunoassay and immunohistochemistry for β-endorphin, we showed that in vitro stimulation of T lymphocytes induced the synthesis and release of β-endorphin and that transfer of T cells into SCID mice increased the expression of β-endorphin in the enteric nervous system. Conclusions: These findings indicate that the immune system is a critical determinant of visceral nociception and that T lymphocytes provide an important opioid-mediated antinociceptive influence in the gut.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gastroenterology - Volume 130, Issue 6, May 2006, Pages 1721-1728
Journal: Gastroenterology - Volume 130, Issue 6, May 2006, Pages 1721-1728
نویسندگان
Monica Verma-Gandhu, Premysl Bercik, Yasuaki Motomura, Elena F. Verdu, Waliul I. Khan, Patricia A. Blennerhassett, Lu Wang, Rami T. El-Sharkawy, Stephen M. Collins,