کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3298513 1209906 2008 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Folate and Vitamin B6 Intake and Risk of Colon Cancer in Relation to p53 Expression
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی بیماری‌های گوارشی
پیش نمایش صفحه اول مقاله
Folate and Vitamin B6 Intake and Risk of Colon Cancer in Relation to p53 Expression
چکیده انگلیسی

Background & Aims: Considerable evidence suggests that a low-folate diet increases the risk of colorectal cancer, although the results of a recent randomized trial indicate that folate supplementation may not reduce the risk of adenoma recurrence. In laboratory models, folate deficiency appears to induce p53 mutation. Methods: We immunohistochemically assayed p53 expression in paraffin-fixed colon cancer specimens in a large prospective cohort of women with 22 years of follow-up to examine the relationship of folate intake and intake of other one-carbon nutrients to risks by tumor p53 expression. Results: A total of 399 incident colon cancers accessible for p53 expression were available. The effect of folate differed significantly according to p53 expression (Pheterogeneity = .01). Compared with women reporting folate intake <200 μg/day, the multivariate relative risks (RRs) for p53-overexpressing (mutated) cancers were 0.54 (95% confidence interval [CI], 0.36–0.81) for women who consumed 200–299 μg/day, 0.42 (95% CI, 0.24–0.76) for women who consumed 300–399 μg/day, and 0.54 (95% CI, 0.35–0.83) for women who consumed ≥400 μg/day. In contrast, total folate intake had no influence on wild-type tumors (RR, 1.05; 95% CI, 0.73–1.51; comparing ≥400 with <200 μg/day). Similarly, high vitamin B6 intake conferred a protective effect on p53-overexpressing cancers (top versus bottom quintile: RR, 0.57; 95% CI, 0.35–0.94; Pheterogeneity = .01) but had no effect on p53 wild-type tumors. Conclusions: We found that low folate and vitamin B6 intake was associated with an increased risk of p53-overexpressing colon cancers but not wild-type tumors.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gastroenterology - Volume 135, Issue 3, September 2008, Pages 770–780
نویسندگان
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