کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3298941 1209917 2007 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Prevalence of Elevated Alanine Aminotransferase Among US Adolescents and Associated Factors: NHANES 1999–2004
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی بیماری‌های گوارشی
پیش نمایش صفحه اول مقاله
Prevalence of Elevated Alanine Aminotransferase Among US Adolescents and Associated Factors: NHANES 1999–2004
چکیده انگلیسی

Background & Aims: Nonalcoholic fatty liver disease (NAFLD) is a common cause of liver disease in children and adolescents. The majority of studies of NAFLD in children have been in select populations of the clinically obese. Study aims were to estimate the prevalence of elevated alanine aminotransferase (ALT, as a marker of NAFLD) in a general contemporary adolescent population and to identify leading risk factors for ALT elevation (>30 U/L). Methods: We analyzed data of adolescent participants (aged 12–19 years; N = 5586) in the National Health and Nutrition Examination Survey 1999–2004, a representative sample of the civilian noninstitutionalized US population. Results: The prevalence of elevated ALT levels (>30 U/L) was 7.4% among white adolescents, 11.5% among Mexican American adolescents, and 6.0% among black adolescents. Elevated ALT levels were prevalent in 12.4% of male subjects compared with 3.5% of female subjects. Multivariable associations with elevated ALT levels were found for sex (odds ratio [OR] male vs female, 7.7; 95% confidence interval [CI], 3.9–15.1), ethnicity (OR black vs white, 0.6; 95% CI, 0.3–1.3; OR Mexican American vs white, 1.6; 95% CI, 1.0–2.6), waist circumference (OR per 1 SD, 1.4; 95% CI, 1.0–2.0), and fasting insulin level (OR per 1 SD, 1.6; 95% CI, 1.2–2.1). Age, C-reactive protein levels, and triglyceride levels were also positively and socioeconomic position inversely associated with elevated ALT levels. The magnitude of associations were similar across ethnic groups. Conclusions: ALT level is associated with waist circumference and insulin resistance even in a young population. These characteristics could be utilized to identify adolescents who may benefit from screening for NAFLD, offering an opportunity to prevent disease progression at an early age.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gastroenterology - Volume 133, Issue 6, December 2007, Pages 1814–1820
نویسندگان
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