کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3302963 1210306 2014 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Clinical outcomes of endoscopic submucosal dissection for superficial Barrett's adenocarcinoma
ترجمه فارسی عنوان
نتایج بالینی تشخیص آندوسکوپی ساب موکوسیال برای آدنوکارسینوم سطحی بارت
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی بیماری‌های گوارشی
چکیده انگلیسی

BackgroundAdvances in diagnostic techniques have allowed early stage detection of superficial Barrett's adenocarcinoma (SBA) as well as resection by endoscopic submucosal dissection (ESD). Few reports exist, however, on the safety and efficacy of ESD for SBA.ObjectiveTo analyze outcomes of ESD for SBA in relation to clinicopathological features of the lesions.DesignRetrospective study.SettingUniversity hospital.PatientsTwenty-three patients (21 men, 2 women; mean age, 63 years) with 26 SBAs.InterventionESD.Main Outcome MeasurementsWe examined outcomes of ESD in relation to the clinicopathological features of SBAs. The main outcomes assessed were en bloc resection rate, operation time, adverse event rates, additional resection rate, and time between ESD and any recurrence.ResultsTwenty lesions (87%) derived from short-segment Barrett's esophagus, and 3 lesions (13%) derived from long-segment Barrett's esophagus. The majority of SBAs (54%) were located in the 0 to 3 o'clock circumferential quadrant. Median tumor size was 15 mm (range 5-60 mm). Macroscopic types were flat elevated (n = 13, 50%), depressed (n = 12, 46%), and protruded (n = 1, 4%). The SBAs appeared red (n = 23, 88%) or normally pale (n = 3, 12%). Under magnifying narrow-band imaging, all SBAs showed an irregular mucosal pattern and an irregular vascular pattern. The endoscopic en bloc resection rate was 100% (26/26), and the pathological en bloc resection rate was 85% (22/26). The median procedure time was 95 minutes (range, 30-210 minutes). Delayed bleeding occurred in 1 case, but there was no perforation. The SBAs were of the differentiated type (n = 25, 96%) or poorly differentiated type (n = 1, 4%). The tumor had invaded the superficial muscularis mucosa (n = 3, 12%), lamina propria mucosa (n = 5, 19%, deep muscularis mucosa (n = 9, 34%), SM1 (n = 3, 12%), and SM2 (n = 6, 23%). Additional surgical resection after ESD was performed in 9 cases, and there were no residual tumors, but 1 lymph node metastasis was found. There were no recurrent tumors; however, 1 metachronous adenocarcinoma was diagnosed 42 months after ESD.LimitationsSingle-center, retrospective study.ConclusionsESD appears to be a safe and effective treatment strategy for early stage SBA.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gastrointestinal Endoscopy - Volume 80, Issue 2, August 2014, Pages 239–245
نویسندگان
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