کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
330393 1433649 2008 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Levodopa increases memory encoding and dopamine release in the striatum in the elderly
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
پیش نمایش صفحه اول مقاله
Levodopa increases memory encoding and dopamine release in the striatum in the elderly
چکیده انگلیسی

Normal aging is associated with a decrease in dopaminergic function and a reduced ability to form new motor memories with training. This study examined the link between both phenomena. We hypothesized that levodopa would (a) ameliorate aging-dependent deficits in motor memory formation, and (b) increase dopamine availability at the dopamine type 2-like (D2) receptor during training in task-relevant brain structures. The effects of training plus levodopa (100 mg, plus 25 mg carbidopa) on motor memory formation and striatal dopamine availability were measured with [11C]raclopride (RAC) positron emission tomography (PET). We found that levodopa did not alter RAC-binding potential at rest but it enhanced training effects on motor memory formation as well as dopamine release in the dorsal caudate nucleus. Motor memory formation during training correlated with the increase of dopamine release in the caudate nucleus. These results demonstrate that levodopa may ameliorate dopamine deficiencies in the elderly by replenishing dopaminergic presynaptic stores, actively engaged in phasic dopamine release during motor training.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Aging - Volume 29, Issue 2, February 2008, Pages 267–279
نویسندگان
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