کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
330440 1433655 2007 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Polymorphisms and haplotypes in the C-reactive protein gene and risk of dementia
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
پیش نمایش صفحه اول مقاله
Polymorphisms and haplotypes in the C-reactive protein gene and risk of dementia
چکیده انگلیسی

ObjectiveInflammation plays a role in the pathogenesis of dementia and Alzheimer's disease (AD). Studies examining serum levels of C-reactive protein in relation to dementia yielded conflicting results. Since serum levels of C-reactive protein are partly determined by genetic factors, we examined the association between genetic variation in the C-reactive protein gene with dementia and AD.MethodsThis study was performed in the Rotterdam Study, a population-based prospective cohort study among elderly. Polymorphisms in the C-reactive protein gene (1184C > T, 2042C > T and 2911C > G) tagging the common haplotypes were genotyped and haplotypes were constructed. During follow-up (mean 9.2 years) 607 dementia cases were identified. We estimated the association between polymorphisms and haplotypes with dementia and AD with Cox’ proportional hazard models.ResultsThe T allele of the C-reactive protein 2042C > T polymorphism, related to lower serum levels of C-reactive protein, was associated with a lower risk of dementia and AD. This association was strongest in APOE ɛ4 allele carriers.ConclusionThese findings suggest that C-reactive protein plays a role in development of dementia.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Aging - Volume 28, Issue 9, September 2007, Pages 1361–1366
نویسندگان
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