کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3305230 1210351 2010 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Prediction of drainage effectiveness during endoscopic stenting of malignant hilar strictures: the role of liver volume assessment
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی بیماری‌های گوارشی
پیش نمایش صفحه اول مقاله
Prediction of drainage effectiveness during endoscopic stenting of malignant hilar strictures: the role of liver volume assessment
چکیده انگلیسی

BackgroundThe optimal endoscopic approach to the drainage of malignant hilar strictures remains controversial, especially with regard to the extent of desirable drainage and unilateral or bilateral stenting.ObjectiveTo identify useful criteria for predicting successful endoscopic drainage.Design and SettingRetrospective 2-center study in the greater Paris area in France.PatientsA total of 107 patients who had undergone endoscopic stenting for hilar tumors Bismuth type II, III, or IV and a set of contemporaneous cross-sectional imaging data available.InterventionsThe relative volumetry of the 3 main hepatic sectors (left, right anterior, and right posterior) was assessed on CT scans. The liver volume drained was estimated and classified into 1 of 3 classes: less than 30%, 30% to 50%, and more than 50% of the total liver volume.Main Outcome MeasurementsThe primary outcome was effective drainage, defined as a decrease in the bilirubin level of more than 50% at 30 days after drainage. Secondary outcomes were early cholangitis rate and survival.ResultsThe main factor associated with drainage effectiveness was a liver volume drained of more than 50% (odds ratio 4.5, P = .001), especially in Bismuth III strictures. Intubating an atrophic sector (<30%) was useless and increased the risk of cholangitis (odds ratio 3.04, P = .01). A drainage > 50% was associated with a longer median survival (119 vs 59 days, P = .005).LimitationsHeterogeneous population and volume assessment methodology to improve in further prospective studies.ConclusionDraining more than 50% of the liver volume, which frequently requires bilateral stent placement, seems to be an important predictor of drainage effectiveness in malignant, especially Bismuth III, hilar strictures. A pre-ERCP assessment of hepatic volume distribution on cross-sectional imaging may optimize endoscopic procedures.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gastrointestinal Endoscopy - Volume 72, Issue 4, October 2010, Pages 728–735
نویسندگان
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