کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3305970 1210362 2010 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Image-guided biopsy in the esophagus through comprehensive optical frequency domain imaging and laser marking: a study in living swine
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی بیماری‌های گوارشی
پیش نمایش صفحه اول مقاله
Image-guided biopsy in the esophagus through comprehensive optical frequency domain imaging and laser marking: a study in living swine
چکیده انگلیسی

BackgroundRandom biopsy esophageal surveillance can be subject to sampling errors, resulting in diagnostic uncertainty. Optical frequency domain imaging (OFDI) is a high-speed, 3-dimensional endoscopic microscopy technique. When deployed through a balloon-centering catheter, OFDI can automatically image the entire distal esophagus (6.0 cm length) in approximately 2 minutes.ObjectiveTo test a new platform for guided biopsy that allows the operator to select target regions of interest on an OFDI dataset, and then use a laser to mark the esophagus at corresponding locations. The specific goals include determining the optimal laser parameters, testing the accuracy of the laser marking process, evaluating the endoscopic visibility of the laser marks, and assessing the amount of mucosal damage produced by the laser.DesignExperimental study conducted in 5 swine in vivo.SettingMassachusetts General Hospital.Main Outcome MeasurementsSuccess rate, including endoscopic visibility of laser marks and accuracy of the laser marking process for selected target sites, and extent of the thermal damage caused by the laser marks.ResultsAll of the laser-induced marks were visible by endoscopy. Target locations were correctly marked with a success rate of 97.07% (95% confidence interval, 89.8%-99.7%). Thermal damage was limited to the superficial layers of the mucosa and was observed to partially heal within 2 days.LimitationsAn animal study with artificially placed targets to simulate pathology.ConclusionsThe study demonstrates that laser marking of esophageal sites identified in comprehensive OFDI datasets is feasible and can be performed with sufficient accuracy, precision, and visibility to guide biopsy in vivo.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gastrointestinal Endoscopy - Volume 71, Issue 2, February 2010, Pages 346–353
نویسندگان
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