کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3306651 | 1210372 | 2011 | 8 صفحه PDF | دانلود رایگان |

BackgroundAccurate preoperative diagnosis and staging of cholangiocarcinoma (CCA) remain difficult.ObjectiveTo evaluate the utility of EUS in the diagnosis and preoperative evaluation of CCA.DesignObservational study of prospectively collected data.SettingSingle tertiary referral hospital in Indianapolis, Indiana.PatientsConsecutive patients with CCA from January 2003 through October 2009.InterventionsEUS and EUS-guided FNA (EUS-FNA).Main Outcome MeasurementsSensitivity of EUS for the detection of a tumor and prediction of unresectability compared with CT and magnetic resonance imaging (MRI); sensitivity of EUS-FNA to provide tissue diagnosis, by using surgical pathology as a reference standard.ResultsA total of 228 patients with biliary strictures undergoing EUS were identified. Of these, 81 (mean age 70 years, 45 men) had CCA. Fifty-one patients (63%) had distal and 30 (37%) had proximal CCA. For those with available imaging, tumor detection was superior with EUS compared with triphasic CT (76 of 81 [94%] vs 23 of 75 [30%], respectively; P < .001). MRI identified the tumor in 11 of 26 patients (42%; P = .07 vs EUS). EUS identified CCA in all 51 (100%) distal and 25 (83%) of 30 proximal tumors (P < .01). EUS-FNA (median, 5 passes; range, 1-12 passes) was performed in 74 patients (91%). The overall sensitivity of EUS-FNA for the diagnosis of CCA was 73% (95% confidence interval, 62%-82%) and was significantly higher in distal compared with proximal CCA (81% vs 59%, respectively; P = .04). Fifteen tumors were definitely unresectable. EUS correctly identified unresectability in 8 of 15 and correctly identified the 38 of 39 patients with resectable tumors (53% sensitivity and 97% specificity for unresectability). CT and/or MRI failed to detect unresectability in 6 of these 8 patients.LimitationSingle-center study.ConclusionEUS and EUS-FNA are sensitive for the diagnosis of CCA and very specific in predicting unresectability. The sensitivity of EUS-FNA is significantly higher in distal than in proximal CCA.
Journal: Gastrointestinal Endoscopy - Volume 73, Issue 1, January 2011, Pages 71–78