کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3306716 | 1210373 | 2008 | 7 صفحه PDF | دانلود رایگان |
BackgroundCystic tumors of the pancreas are frequently detected and encompass a wide pathologic spectrum, ranging from benign to malignant. A substantial proportion of cystic tumors cannot be histologically classified, even after extensive diagnostic evaluation, and, therefore, ultimately require surgical resection. Recently, complete resolution of cystic tumors by EUS-guided ethanol lavage was reported in a pilot study.ObjectivesThe aim of this study was to evaluate the safety, feasibility, and response after EUS-guided ethanol lavage with paclitaxel injection (EUS-EP) for cystic tumors of the pancreas.DesignA prospective study.SettingA tertiary care, academic medical center, from July 2005 to November 2006.PatientsFourteen patients who underwent EUS-EP were observed for more than 6 months. They were analyzed in terms of procedure safety, feasibility, and response.InterventionEUS-EP.Main Outcome MeasurementsTo compare changes of cyst volume before and after an EUS-EP.ResultsAn EUS-EP was successfully performed in all cases except one patient in whom the cyst fluid was so viscous that it could not be sufficiently aspirated. Acute pancreatitis occurred in one patient, and minor complications, including hyperamylasemia (n = 6) and vague abdominal pain (n = 1), were observed. Complete resolution of a cystic tumor was observed in 11 patients and partial resolution in two patients, and a cyst persisted in one patient.LimitationsA small patient number, a short follow-up time, a single treatment arm.ConclusionsEUS-EP appears to be a safe, feasible, and effective method for treating cystic tumors of the pancreas. Further studies that involve larger populations and longer follow-ups are warranted.
Journal: Gastrointestinal Endoscopy - Volume 67, Issue 4, April 2008, Pages 636–642